Cannabidiol: from an inactive cannabinoid to a drug with wide spectrum of action

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OBJECTIVE:

The
aim
of
this
review
is
to
describe
the
historical
development
of
research
on
cannabidiol.

METHOD:

This
review
was
carried
out
on
reports
drawn
from
Medline,
Web
of
Science
and
SciELO.

DISCUSSION:

After
the
elucidation
of
the
chemical
structure
of
cannabidiol
in
1963,
the
initial
studies
showed
that
cannabidiol
was
unable
to
mimic
the
effects
of Cannabis.
In
the
1970’s
the
number
of
publications
on
cannabidiol
reached
a
first
peak,
having
the
research
focused
mainly
on
the
interaction
with
delta9-THC
and
its
antiepileptic
and
sedative
effects.
The
following
two
decades
showed
lower
degree
of
interest,
and
the
potential
therapeutic
properties
of
cannabidiol
investigated
were
mainly
the
anxiolytic,
antipsychotic
and
on
motor
diseases
effects.
The
last
five
years
have
shown
a
remarkable
increase
in
publications
on
cannabidiol
mainly
stimulated
by
the
discovery
of
its
anti-inflammatory,
anti-oxidative
and
neuroprotective
effects.
These
studies
have
suggested
a
wide
range
of
possible
therapeutic
effects
of
cannabidiol
on
several
conditions,
including
Parkinson’s
disease,
Alzheimer’s
disease,
cerebral
ischemia,
diabetes,
rheumatoid
arthritis,
other
inflammatory
diseases,
nausea
and
cancer.

CONCLUSION:

In
the
last
45
years
it
has
been
possible
to
demonstrate
that
CBD
has
a
wide
range
of
pharmacological
effects,
many
of
which
being
of
great
therapeutic
interest,
but
still
waiting
to
be
confirmed
by
clinical
trials.

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